Wet milling in API differ from jet milling
It’s important to understand the fundamental differences between Wahal’s wet milling solutions and jet milling in API development. Here’s a breakdown and a comparative chart:
Key Differences:
- Medium:
- Wet Milling: Uses a liquid medium (solvent) to suspend the API.
- Jet Milling: Uses high-pressure gas (typically air or nitrogen).
- Mechanism:
- Wet Milling: Particle size reduction occurs through shear, impact, and attrition within the liquid.
- Jet Milling: Particle size reduction occurs through high-velocity collisions between particles.
- Environment:
- Wet Milling: Occurs within a liquid environment.
- Jet Milling: Occurs in a dry, gaseous environment.
Comparative Chart:
| Feature | Wet Milling | Jet Milling |
| Medium | Liquid | Gas |
| Mechanism | Shear, impact, attrition | Particle-particle collisions |
| Heat Generation | Liquid helps dissipate heat | Potential for heat generation |
| Suitability for Heat-Sensitive APIs | Good | Can be problematic |
| Suitability for Static-Sensitive APIs | Good | Can be problematic |
| Particle Size Control | Good, influenced by processing parameters | Good, influenced by gas pressure and flow |
| Risk of Contamination | Potential from liquid medium | Potential from gas or equipment |
| Yield Loss | Typically lower | Potential for higher yield loss |
| Solvent usage | requires solvents | does not require solvents |
| Containment requirements | Generally less stringent | Can require more stringent containment, especially for potent compounds |