Wet milling of API Powders differs from jet milling
It’s important to understand the fundamental differences between Wahal’s wet milling solutions and jet milling in API development. Here’s a breakdown and a comparative chart:
Key Differences:
- Medium:
- Wet Milling: Uses a liquid medium (solvent) to suspend the API.
- Jet Milling: Uses high-pressure gas (typically air or nitrogen).
- Mechanism:
- Wet Milling: Particle size reduction occurs through shear, impact, and attrition within the liquid.
- Jet Milling: Particle size reduction occurs through high-velocity collisions between particles.
- Environment:
- Wet Milling: Occurs within a liquid environment.
- Jet Milling: Occurs in a dry, gaseous environment.
Comparative Chart:
| Feature | Wet Milling | Jet Milling |
| Medium | Liquid | Gas |
| Mechanism | Shear, impact, attrition | Particle-particle collisions |
| Heat Generation | Liquid helps dissipate heat | Potential for heat generation |
| Suitability for Heat-Sensitive APIs | Good | Can be problematic |
| Suitability for Static-Sensitive APIs | Good | Can be problematic |
| Particle Size Control | Good, influenced by processing parameters | Good, influenced by gas pressure and flow |
| Risk of Contamination | Potential from liquid medium | Potential from gas or equipment |
| Yield Loss | Typically lower | Potential for higher yield loss |
| Solvent usage | requires solvents | does not require solvents |
| Containment requirements | Generally less stringent | Can require more stringent containment, especially for potent compounds |
Pharma-compliant design – with Wahal
validation concept
The qualification documents DQ, IQ, OQ that are required for
validation or the certificates for the process-relevant machine
components such as calibration- and materials certificates are
available for all Wahal high shear mixer. On request, we can also carry
out the Factory Acceptance Test in our factory or the Site
Acceptance Test at your production site